tigecycline (Rx)

Adult: IV 100 mg, then 50 mg q12 hr, IV INF is given over 30 min to 60 min q12 hr; given for 5-14 days depending on infection Hepatic dose (Child-Pugh C)

Adult: IV 100 mg, then 25 mg q12 hr

Available forms: Powder for inj, lyophilized 50 mg

Implementation - Tigecycline allergy test before using, obtain C&S, do not begin treatment before results Intermittent IV infusion route - Reconstitute each vial with 5.3 ml of 0.9% NaCl, or D5 W (10 mg/ml); swirl to dissolve; immediately withdraw 5 ml of the reconstituted sol and add to a 100-ml IV bag for inf (1 mg/ml); may be yellow or orange, if not, sol should be discarded; do not give if particulate matter is present, use a dedicated IV line or Y-site, flush with NS before and after use, give over ½ hr - Store in tight, light-resistant container at room temperature, diluted sol at room temp for up to 24 hr, 6 hr in vial, and remaining time in IV bag, 48 hr refrigerated

Y-site compatibilities: Acyclovir, alfentanil, allopurinol, amifostine, amikacin, aminocaproic acid, aminophylline, amphotericin B liposome, ampicillin, ampicillin/sulbactam, argatroban, azithromycin, aztreonam, bivalirudin, bumetanide, buprenorphine, butorphanol, calcium chloride/gluconate, CARBOplatin, carmustine, caspofungin, ceFAZolin, cefepime, cefotaxime, cefoTEtan, cefOXitin, cefTAZidime, ceftizoxime, cefTRIAXone, cefuroxime, cimetidine, ciprofloxacin, cisatracurium, CISplatin, clindamycin, cyclophosphamide, cycloSPORINE, cytarabine, dacarbazine, DACTINomycin, DAPTOmycin, DAUNOrubicin hydrochloride, dexamethasone, dexmedetomidine, dexrazoxane, digoxin, diltiazem, diphenhydrAMINE, DOBUTamine, DOCEtaxel, dolasetron, DOPamine, doripenem, DOXOrubicin hydrochloride, DOXOrubicin liposome, droperidol, enalaprilat, EPINEPHrine, eptifibatide, ertapenem, erythromycin, esmolol, etoposide, etoposide phosphate, famotidine, fenoldopam, fentaNYL, fluconazole, fludarabine, fluorouracil, foscarnet, fosphenytoin, furosemide, ganciclovir, gemcitabine, gentamicin, glycopyrrolate, granisetron, haloperidol, heparin, hydrocortisone, HYDROmorphone, ifosfamide, imipenem/cilastatin, insulin, irinotecan, isoproterenol, ketorolac, labetalol, lansoprazole, lepirudin, leucovorin, levofloxacin, lidocaine, linezolid, LORazepam, magnesium sulfate, mannitol, mechlorethamine, melphalan, meperidine, meropenem, mesna, methohexital, methotrexate, methyldopa, metoclopramide, metoprolol, metroNIDAZOLE, midazolam, milrinone, mitoMYcin, mitoXANtrone, morphine, moxifloxacin, mycophenolate, nafcillin, nalbuphine, naloxone, nesiritide, nitroglycerin, nitroprusside, norepinephrine, octreotide, ondansetron, oxaliplatin, oxytocin, PACLitaxel, palonosetron, pamidronate, pancuronium, pantoprazole, PEMEtrexed, pentamidine, pentazocine, PENTobarbital, PHENobarbital, phenylephrine, piperacillin/tazobactam, potassium acetate/chloride/phosphate, procainamide, prochlorperazine, promethazine, propofol, propranolol, ranitidine, remifentanil, rocuronium, sodium acetate/bicarbonate/phosphate, streptozocin, succinylcholine, SUFentanil, tacrolimus, teniposide, theophylline, thiopental, thiotepa, ticarcillin/clavulanate, tirofiban, tobramycin, topotecan, trimethoprim/sulfamethoxazole, vancomycin, vasopressin, vecuronium, vinBLAStine, vinCRIStine, vinorelbine, zidovudine, zoledronic acid Y-site incompatibilities: Amiodarone, amphotericin B colloidal, bleomycin, chloramphenicol, chlorproMAZINE, dantrolene, DAUNOrubicin liposome, diazepam, epirubicin, hydrALAZINE, IDArubicin, niCARdipine, phenytoin, quinapristin/dalfopristin, verapamil